Photodynamic therapy is called the fourth tumor therapy following surgery, chemotherapy and radiotherapy abroad. It was approved to Clinical Application more than 20 years ago in USA, Japan, UK, France, Germany, Canada, South Korea, Russia and other countries. China began the Clinical Application of this therapy in the middle or late of 1990s. At present, photodynamic therapy is used for treatment of bronchogenic carcinoma, gastric cancer, esophageal cancer, nasopharyngeal cancer, bladder cancer, pancreatic cancer, skin cancer, urinary and reproductive tract tumors. In the non-neoplastic diseases it is primarily for the treatment of macular fundus, nevus flammeus, condyloma acuminatum.